More recently, X ray structural work has demonstrated that when different ER ligands such as estradiol E2, tamoxifen, Ral, and the antiestrogen ICI 182, 780 ICI interact with the ligand binding domain of the receptor, distinctly different conformations of the receptor are induced 12, 13, 14, 15 augmentin where to buy Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by amikacin or other antibacterial drugs in the future